medium · LSAT Reading Comprehension

After confirming that the adult hippocampus generates functional neurons that integrate into circuits and aid learning, a neurogenesis passage concludes that the path to clinical therapies is likely to be long and uncertain. The passage notes two complications: neurogenesis appears to occur at a much lower rate in humans than in the animal models where it has been studied, and a freshly generated neuron confers no benefit unless it completes a demanding integration into existing circuits. Environmental enrichment is shown to increase hippocampal neurogenesis in adult animal models.

Which one of the following pieces of evidence most directly supports the passage's cautious conclusion about clinical therapies?

  1. Human neurogenesis occurs at a substantially lower rate than the rate seen in animal models.
  2. Hippocampal neurogenesis has no effect whatsoever on memory formation in humans.
  3. The medical community has shown little interest in pursuing endogenous neuronal regeneration.
  4. Environmental enrichment increases neurogenesis only in childhood and never in adulthood.
  5. Newly generated neurons grow larger than the existing neurons in the adult hippocampus.

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