medium · NCLEX-RN health-promotion
A pregnant client at 11 weeks gestation is seen in the prenatal clinic. Both she and her partner are confirmed carriers of the cystic fibrosis F508del mutation. The couple wants a definitive prenatal diagnostic test to determine if the fetus is affected as early as safely possible.
Which test should the nurse discuss with the client?
- Chorionic villus sampling (CVS) of the placenta, which can be performed at this visit to obtain fetal cells for DNA mutation analysis.
- Maternal serum cell-free DNA (cfDNA) screening, which can be done immediately to definitively diagnose fetal cystic fibrosis, for this client.
- Percutaneous umbilical blood sampling (PUBS) to measure fetal sweat chloride levels at 12 weeks gestation.
- Amniocentesis for fetal gene analysis, which can be safely performed at 11 weeks gestation using a transabdominal needle, for this client.
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