hard · NCLEX-RN Pharmacological and Parenteral Therapies

A nurse is administering a cisplatin infusion to a 55-year-old client with non-small cell lung cancer. Which clinical assessments or nursing interventions are critical for preventing or detecting cisplatin-induced toxicities? Select all that apply.

  1. Hold the medication and notify the provider if the serum creatinine rises above baseline or if urine output is less than 30 mL/hr.
  2. Administer a high-dose loop diuretic reflexively if urine output drops, without checking current renal function labs.
  3. Perform a baseline audiogram and monitor the client for reports of tinnitus or hearing loss.
  4. Maintain aggressive intravenous hydration with normal saline at 150 mL/hr as ordered during and after the therapy.
  5. Keep the client on a strict low-sodium, fluid-restricted diet during the infusion cycles.
  6. Monitor serum magnesium and potassium levels frequently during therapy.

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