medium · NCLEX-RN Pharmacological and Parenteral Therapies

The RN is reviewing laboratory results for a client receiving high-dose methotrexate.

Which finding represents a 'Toxicity marker' requiring immediate leucovorin rescue timing evaluation?

  1. The presence of mild oral mucositis (Grade 1), for this client.
  2. A serum potassium of 3.8 mEq/L.
  3. A 50% rise in serum creatinine from the client's baseline.
  4. An absolute neutrophil count (ANC) of 2,500/mm3, for this client.

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