medium · NCLEX-RN Pharmacological and Parenteral Therapies

The RN is monitoring a client receiving chimeric antigen receptor (CAR) T-cell therapy. The client's temperature has risen from 37.0°C to 38.5°C in two hours.

Which interpretation by the nurse is most accurate based on the clinical judgment cycle?

  1. The nurse should administer acetaminophen and reassess in four hours.
  2. The fever is likely due to an underlying neutropenic infection and requires immediate antibiotics.
  3. The finding represents a potential onset of cytokine release syndrome (CRS) requiring escalation.
  4. This is an expected inflammatory response to cell lysis and requires only routine monitoring.

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