medium · MCAT bio-biochem

In prolonged fasting or untreated diabetes, the body produces ketone bodies.

Which of the following best describes the biochemical source of ketones and their clinical impact on blood chemistry?

  1. Ketones are produced from excess Acetyl-CoA during high beta-oxidation; their accumulation leads to metabolic acidosis.
  2. Ketones are produced from the breakdown of proteins in the muscle; their accumulation leads to high blood urea nitrogen (BUN).
  3. Ketones are produced from the incomplete oxidation of glucose in the brain; their accumulation leads to respiratory alkalosis.
  4. Ketones are synthesized from lactate via the glyoxylate cycle; their accumulation leads to hypoglycemia.

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