MCAT Practice Questions

MCAT practice questions across the sciences and CARS, written to test mechanism-level understanding rather than recall. Full explanations connect each answer back to the underlying physiology, chemistry, or reasoning principle.

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KomFi publishes free MCAT practice questions with full passage structure. A free account unlocks the complete bank, explanations, flashcards, and your percentile rank.

Free MCAT practice questions

  1. A researcher discovers that a population of bacteria survives exposure to an antibiotic because a few individu
  2. Which structure is most likely dysfunctional?
  3. What genetic term describes a single gene influencing multiple seemingly unrelated traits?
  4. Which organelle would you expect to be exceptionally well-developed in these cells?
  5. An electrophysiologist observes a neuron at its resting memb… — Which ion is primarily responsible for this de
  6. In the human ear, sound waves cause fluid in the cochlea to… — Which cells are responsible for converting thes
  7. Which of the following changes would result in a decrease in the P_50 value of hemoglobin?
  8. In the lung alveoli, the P_CO_2 is relatively low and the pH… — How do these conditions facilitate the functio
  9. What is the frequency of the heterozygous genotype (2pq)?
  10. A sprinter finishes a 400-meter dash and has an accumulation… — Which statement best describes the Bohr effect
  11. A protein signal binding to a cell surface receptor leads to… — What is the expected outcome of this activatio
  12. A patient is admitted to the emergency department with a sev… — How does this patient's O_2 saturation at a ti
  13. A patient with severe dehydration is likely to exhibit which of the following physiological responses to maint
  14. Which of the following describes the immediate effect on the resting membrane potential of their neurons?
  15. A molecule moves into a cell against its concentration gradient using energy provided by a pre-existing sodium
  16. A test cross is performed by mating an individual of dominant phenotype but unknown genotype with an individua
  17. Which observation correctly explains the different O_2 binding behaviors?
  18. Which molecule acts as a 'fluidity buffer' in animal cell membranes?
  19. A scientist is tracking the movement of a secreted protein. If the protein has just left the 'trans' face of t
  20. A researcher is studying two genes that are located very close to each other on the same chromosome. They noti
  21. What is the expected position of their oxygen-hemoglobin dissociation curve relative to the standard?
  22. Which equation correctly illustrates the chemical basis for the 'acid' component of this shift?
  23. A population of flowers is in Hardy-Weinberg equilibrium. Th… — What is the frequency of the dominant allele
  24. During a state of severe dehydration, which of the following describes the synergistic action of ADH and aldos
  25. An athlete is sprinting a 100-meter dash. Which of the following best describes the metabolic fate of pyruvate

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