hard · MCAT bio-biochem
A 32-year-old patient presents with a severe infection by a virulent extracellular bacterium.
Which of the following best describes the coordinated adaptive immune response required to clear this specific pathogen?
- Infected host cells present bacterial peptides via MHC I to CD8⁺ T-cells, which release perforins to induce apoptosis in the target cells.
- Macrophages present bacterial antigens via MHC II to CD4⁺ T-cells, inducing T_h2 differentiation and B-cell antibody class switching.
- Dendritic cells present bacterial antigens via MHC I to CD4⁺ T-cells, leading to the recruitment of neutrophils and the secretion of IFN-γ.
- Natural Killer cells recognize the lack of MHC II on the bacterial surface and release interferons to activate the complement system's membrane attack complex.
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