easy · MCAT bio-biochem

Anaphylaxis is a severe systemic allergic reaction triggered by the rapid release of histamine.

Which of the following best explains why blood pressure collapses during this crisis?

  1. Histamine causes widespread systemic vasoconstriction and sharply decreases capillary permeability throughout the body.
  2. Histamine causes widespread vasodilation and increased capillary permeability, leading to fluid loss from the circulation.
  3. The heart rate slows down to extremely low levels, entirely failing to maintain adequate cardiac output during the reaction.
  4. Circulating antibodies directly bind to and neutralize the epinephrine released by the adrenal glands during the stress response.

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