medium · MCAT bio-biochem

A researcher is studying dopamine signaling in patients with schizophrenia.

Which of the following is the most accurate doctrinal description of the neurochemical findings in this disorder?

  1. Dopamine dysregulation, often involving hyperactivity in the mesolimbic pathway.
  2. An absolute excess of dopamine throughout the entire central nervous system.
  3. The degeneration of dopaminergic neurons in the substantia nigra.
  4. A global deficiency of dopamine that causes negative symptoms like flat affect.

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