medium · MCAT bio-biochem

A scientist compares the mechanism of action of Insulin (a peptide hormone) and Testosterone (a steroid hormone).

Which of the following statements correctly describes their behavior at the cellular level?

  1. Insulin produces long-lasting, slow-onset effects on target cells, whereas Testosterone instead produces much more rapid, short-lived effects overall.
  2. Both hormones require a dedicated protein carrier to travel freely through the bloodstream, and both ultimately bind to the same cytosolic receptor type.
  3. Insulin enters the nucleus directly to act as a transcription factor regulating gene expression, while Testosterone instead activates a G-protein-coupled receptor.
  4. Insulin binds to a cell-surface receptor and triggers a second-messenger cascade; Testosterone binds to an intracellular receptor to alter gene expression.

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