medium · MCAT chem-phys
An investigator is analyzing a ventricular pressure-volume loop.
If the area of the loop represents 'stroke work,' which of the following changes would most significantly increase this area?
- Decreasing heart rate while stroke volume stays constant across beats.
- Raising both EDV and ESV equally (e.g., 20 mL), leaving SV unchanged.
- Increasing end-diastolic volume while maintaining a constant end-systolic volume.
- Lowering the aortic pressure the ventricle overcomes during the ejection phase of systole.
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