medium · MCAT chem-phys
Which of the following describes the correct order of bond reactivity for carboxylic acid derivatives in nucleophilic acyl substitution, from most reactive to least reactive?
- Amide > Ester > Anhydride > Acid Chloride
- Acid Chloride > Ester > Anhydride > Amide
- Ester > Amide > Acid Chloride > Anhydride
- Acid Chloride > Anhydride > Ester > Amide
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