medium · MCAT chem-phys

Which of the following describes the correct order of bond reactivity for carboxylic acid derivatives in nucleophilic acyl substitution, from most reactive to least reactive?

  1. Amide > Ester > Anhydride > Acid Chloride
  2. Acid Chloride > Ester > Anhydride > Amide
  3. Ester > Amide > Acid Chloride > Anhydride
  4. Acid Chloride > Anhydride > Ester > Amide

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