hard · MCAT
In the human liver, which of the following best explains why Acetyl-CoA derived from fatty acid beta-oxidation cannot be used to synthesize glucose via gluconeogenesis?
- Acetyl-CoA inhibits the enzyme pyruvate carboxylase.
- The liver lacks the enzymes for the citric acid cycle.
- The reaction catalyzed by the pyruvate dehydrogenase complex is irreversible.
- Fatty acids are strictly used for ATP production and cannot enter metabolic pathways.
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