hard · MCAT

A cell is undergoing glycolysis in a strictly anaerobic environment.

Which of the following best describes the net ATP yield per glucose molecule and the primary metabolic purpose of the subsequent fermentation step?

  1. Net yield of 4 ATP; fermentation serves to neutralize the pH drop caused by the production of lactic acid.
  2. Net yield of 30-32 ATP; fermentation serves to shuttle electrons into the mitochondria via the malate-aspartate shuttle.
  3. Net yield of 2 ATP; fermentation serves to produce additional ATP through the reduction of pyruvate.
  4. Net yield of 2 ATP; fermentation serves to regenerate NAD⁺ from NADH to allow glycolysis to continue.

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