hard · MCAT

Hemoglobin's affinity for oxygen is modulated by several physiological factors.

Which of the following conditions would result in a rightward shift of the oxygen-dissociation curve (the Bohr effect)?

  1. Increased partial pressure of CO₂ and decreased pH.
  2. Decreased temperature and increased pH.
  3. Decreased concentration of 2,3-bisphosphoglycerate (2,3-BPG).
  4. Fetal hemoglobin (HbF) replacing adult hemoglobin (HbA).

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