hard · MCAT

A researcher discovers a mutation that prevents the formation of the Na^+/K^+ pump in a specific line of cells.

Which of the following would be the most immediate consequence for the cell's resting membrane potential?

  1. The concentration gradients for Na⁺ and K⁺ will gradually dissipate, and the resting potential will eventually reach 0 mV.
  2. The membrane potential will lock at +30 mV, the peak of the action potential.
  3. The action potential will fire spontaneously and continuously due to the lack of regulation.
  4. The cell will immediately hyperpolarize to -90 mV as K⁺ ions continue to leak out.

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