hard · MCAT
A researcher observes that a specific muscle cell line shows significantly decreased flux through the glycolytic pathway despite high concentrations of glucose. Analysis reveals abnormally high intracellular ATP levels.
Which regulatory mechanism is most likely responsible?
- Activation of Pyruvate Dehydrogenase to increase Acetyl-CoA production.
- Competitive inhibition of Hexokinase by Glucose-6-Phosphate.
- Increased expression of GLUT4 transporters on the plasma membrane.
- Allosteric inhibition of Phosphofructokinase-1 (PFK-1).
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