medium · MCAT bio-biochem
A patient is unable to reabsorb glucose in their proximal convoluted tubule, resulting in glucose in the urine (glycosuria). Physiologically, this most likely occurs because:
- Antidiuretic Hormone (ADH) is inhibiting tubular reabsorption of filtered sugar in the nephron segments.
- The loop of Henle fails to create a sufficient osmotic gradient in the renal medulla.
- The glomerulus has become too permeable, allowing excess glucose to enter the tubular filtrate.
- The blood glucose concentration has exceeded the transport maximum (T_m) of the carrier proteins
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