medium · MCAT bio-biochem

An athlete is sprinting a 100-meter dash. Which of the following best describes the metabolic fate of pyruvate in their active muscle cells during this intense, short-duration exercise?

  1. Pyruvate is transported to the mitochondria to be converted into acetyl-CoA for the Citric Acid Cycle.
  2. Pyruvate is reduced to lactate in the cytoplasm to regenerate NAD^+ for continued glycolysis.
  3. Pyruvate is decarboxylated into ethanol to prevent the buildup of acidic metabolites.
  4. Pyruvate is converted to glucose via gluconeogenesis within the muscle cell to provide more fuel.

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