medium · MCAT bio-biochem

Acute stress triggers the 'fight-or-flight' response via the adrenal medulla, while chronic stress involves the adrenal cortex.

How do the signaling mechanisms of epinephrine and cortisol differ in terms of their molecular interaction with target cells?

  1. Cortisol binds to a receptor tyrosine kinase (RTK) on the cell surface; Epinephrine instead relies on a voltage-gated ion channel.
  2. Epinephrine enters the nucleus to directly induce new protein synthesis; Cortisol instead activates an enzymatic cascade in the cytoplasm.
  3. Epinephrine binds to cell-surface G-protein coupled receptors; Cortisol binds to intracellular receptors that act as transcription factors.
  4. Both hormones bind to ligand-gated ion channels embedded within the plasma membrane, together inducing rapid depolarization of the target cell.

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