medium · MCAT bio-biochem
In the lung alveoli, the P_CO_2 is relatively low and the pH is slightly higher than in the systemic tissues.
How do these conditions facilitate the function of hemoglobin?
- They shift the curve to the left, maximizing the loading of oxygen onto hemoglobin.
- They shift the curve to the right, helping to displace CO_2 with O_2 through the Bohr effect.
- They increase the P_50 to 40 mmHg so that hemoglobin can 'grab' oxygen from the air more aggressively.
- They stabilize the carbaminohemoglobin form to prevent oxygen from binding prematurely.
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