medium · MCAT bio-biochem

Cyanide binds irreversibly to Complex IV of the electron transport chain, preventing the transfer of electrons to oxygen.

In a cell treated with cyanide, what is the most immediate metabolic consequence for the Citric Acid Cycle?

  1. Pyruvate is converted directly to Citrate in the cytoplasm.
  2. The cycle accelerates to compensate for lost ATP production.
  3. The cycle halts due to a depletion of NAD⁺ and FAD.
  4. The cycle continues normally but switches to using NADP⁺.

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