medium · MCAT bio-biochem
A 45-year-old patient with chronic heart failure is prescribed a β-agonist to improve cardiac contractility.
In cardiac myocytes, the binding of epinephrine to the β_1-adrenergic receptor triggers which specific sequence of intracellular events?
- Activation of G_i protein, inhibition of adenylate cyclase, decreased cAMP, and inhibition of Protein Kinase A.
- Activation of G_s protein, stimulation of adenylate cyclase, increased cAMP, and activation of Protein Kinase A.
- Activation of G_q protein, stimulation of phospholipase C, increased IP_3, and activation of Protein Kinase C.
- Activation of a Receptor Tyrosine Kinase, auto-phosphorylation, and recruitment of IRS-1.
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