medium · MCAT bio-biochem
A 35-year-old male is treated with a drug that inhibits the enzyme acetylcholinesterase at the neuromuscular junction.
What is the most likely physiological consequence for the skeletal muscles?
- Prolonged muscle contraction and potential spasms due to the persistence of acetylcholine in the synaptic cleft.
- Increased rate of repolarization occurring rapidly in the postsynaptic muscle membrane after each stimulus.
- Blocking of the voltage-gated sodium channels on the muscle fiber's sarcolemma, preventing an action potential.
- Flaccid paralysis resulting from the motor neuron terminal's inability to release stored acetylcholine into the synaptic cleft.
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