medium · MCAT bio-biochem

A patient with uncontrolled diabetes experiences an increase in blood glucose, causing the filtrate in the nephron to exceed the transport maximum for glucose reabsorption.

What is the osmotic consequence in the collecting duct?

  1. Water remains in the tubule due to the osmotic pressure of the glucose, leading to polyuria.
  2. ADH secretion increases, causing all water to be reabsorbed despite the glucose presence.
  3. Glucose is actively secreted in the distal tubule to lower blood sugar.
  4. The loop of Henle becomes more efficient at pumping salt to compensate for the glucose.

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