medium · MCAT bio-biochem
A patient with severe insulin resistance is treated with a drug that modifies the rate-limiting step of glycolysis in the liver.
Which enzyme is most likely targeted, and how is it regulated by high ATP levels?
- Phosphofructokinase-1 (PFK-1); it is allosterically inhibited by ATP.
- Hexokinase; it is inhibited in a competitive manner by excess ATP
- Glucokinase; it is inhibited by ATP indirectly via allosteric phosphorylation
- Pyruvate kinase, the final regulated enzyme in glycolysis, is activated by ATP
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