medium · MCAT bio-biochem
A patient with severe insulin resistance is treated with a drug that modifies the rate-limiting step of glycolysis in the liver.
Which enzyme is most likely targeted, and how is it regulated by high ATP levels?
- Phosphofructokinase-1 (PFK-1); it is allosterically inhibited by ATP.
- Hexokinase; it is competitively inhibited by ATP.
- Glucokinase; it is inhibited by ATP via phosphorylation.
- Pyruvate kinase; it is activated by ATP.
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