medium · MCAT bio-biochem
A patient presents with extreme dehydration. The body's homeostatic response involves the release of Antidiuretic Hormone (ADH) and Aldosterone.
Which of the following accurately describes the primary mechanism by which Aldosterone acts on the nephron to restore blood volume?
- It increases the permeability of the collecting duct to water by directly inserting new aquaporin channels.
- It increases the expression of Na^+/K^+ pumps in the distal tubule, leading to osmotic water reabsorption.
- It inhibits the Na^+/Cl^- cotransporters located specifically in the thick Ascending Loop of Henle segment.
- It decreases the hydrostatic pressure within the glomerular capillaries, thereby reducing the glomerular filtration rate.
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