medium · MCAT bio-biochem
A 45-year-old male with Type 1 Diabetes Mellitus receives a bolus of insulin.
Which of the following best describes the initial signaling event upon insulin binding to its target receptor?
- Receptor dimerization followed by autophosphorylation of tyrosine residues on the intracellular domain.
- Opening of a ligand-gated ion channel allowing the influx of Ca^2+ ions into the cytosol.
- Binding to an intracellular receptor that translocates to the nucleus to act as a transcription factor.
- Activation of a G-protein followed by the production of cAMP by adenylate cyclase.
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