medium · MCAT bio-biochem

The nephron maintains a steep osmotic gradient in the renal medulla to facilitate water reabsorption.

Which of the following correctly describes the roles of the loop of Henle and Antidiuretic Hormone (ADH) in this process?

  1. A salty medulla is created by the collecting duct, and the loop of Henle uses this salt to produce a large volume of dilute urine.
  2. ADH binds to the loop of Henle to increase the active transport of sodium into the blood.
  3. The descending limb of the loop of Henle actively pumps out salt to create a dilute medulla.
  4. The loop of Henle establishes the medullary osmotic gradient via countercurrent multiplication, while ADH increases water permeability in the collecting duct.

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