medium · MCAT bio-biochem
A 45-year-old patient with untreated Type 1 Diabetes presents with severe hyperglycemia.
Which of the following homeostatic responses would be expected if the body's negative feedback systems were functioning correctly, and why is this response absent or ineffective in this patient?
- The liver would normally convert glucose to glycogen; however, insulin resistance prevents this process.
- Glucagon release would normally lower blood glucose; however, the α-cells are hyperactive.
- Insulin release would normally lower blood glucose by promoting cellular uptake; however, the pancreatic β-cells are destroyed.
- The kidneys would normally reabsorb all glucose to prevent energy loss; however, the transport maximum (T_m) has been exceeded.
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