hard · LSAT Logical Reasoning

In a clinical trial, patients who took a new cholesterol drug had 25 percent fewer heart attacks over five years than patients who received no treatment. The drug's manufacturer concluded that the drug directly prevents heart attacks and should be prescribed broadly to at-risk patients.

Which one of the following, if true, most weakens the manufacturer's conclusion?

  1. The drug is somewhat more expensive to manufacture than several older cholesterol medications already approved for widespread use.
  2. Heart attack rates in the general population have declined gradually over the past several decades due to numerous public health factors.
  3. Patients taking the drug reported that their monthly checkups felt more thorough than any previous medical visits they recalled.
  4. The new cholesterol drug is completely unable to lower any patient's cholesterol level by any measurable amount whatsoever.
  5. Patients given the drug also had to attend monthly checkups that included diet and exercise counseling, unlike the untreated group.

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